Blar i forfatter "Edfors, Fredrik"

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    • Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism 

      Iglesias, Maria Jesus; Sanchez-Rivera, Laura; Ibrahim-Kosta, Manal; Naudin, Clément; Munsch, Gaëlle; Goumidi, Louisa; Farm, Maria; Smith, Philip M.; Thibord, Florian; Kral-Pointner, Julia Barbara; Hong, Mun-Gwan; Suchon, Pierre; Germain, Marine; Schottmaier, Waltraud; Dusart, Philip James; Boland, Anne; Kotol, David; Edfors, Fredrik; Koprulu, Mine; Pietzner, Maik; Langenberg, Claudia; Damrauer, Scott M.; Johnson, Andrew D.; Klarin, Derek M.; Smith, Nicholas L.; Smadja, David M.; Holmström, Margareta; Magnusson, Maria; Silveira, Angela; Uhlén, Mathias; Renné, Thomas; Martinez-Perez, Angel; Emmerich, Joseph; Deleuze, Jean-Francois; Antovic, Jovan; Soria Fernandez, Jose Manuel; Assinger, Alice; Schwenk, Jochen M.; Souto Andres, Joan Carles; Morange, Pierre-Emmanuel; Butler, Lynn; Trégouët, David-Alexandre; Odeberg, Jacob (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-07)
      Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction. Here we show, using proteomics profiling to screen plasma from patients with suspected acute VTE, and several case-control studies for VTE, how Complement ...

    • Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling 

      Dodig-Crnković, Tea; Hong, Mun-Gwan; Engel Thomas, Cecilia; Häussler, Ragna S.; Bendes, Annika; Dale, Matilda; Edfors, Fredrik; Forsström, Björn; Magnusson, Patrik K.E.; Schuppe-Koistinen, Ina; Odeberg, Jacob Olof; Fagerberg, Linn; Gummesson, Anders; Bergström, Göran; Mathias, Uhlén; Schwenk, Jochen M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-03)
      Background: Precision medicine approaches aim to tackle diseases on an individual level through molecular profiling. Despite the growing knowledge about diseases and the reported diversity of molecular phenotypes, the descriptions of human health on an individual level have been far less elaborate.<p> <p>Methods: To provide insights into the longitudinal protein signatures of well-being, we ...

    • Proteomics in thrombosis research 

      Edfors, Fredrik; Iglesias, Maria Jesus; Butler, Lynn; Odeberg, Jacob (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-25)
      A State of the Art lecture titled “Proteomics in Thrombosis Research” was presented at the ISTH Congress in 2021. In clinical practice, there is a need for improved plasma biomarker-based tools for diagnosis and risk prediction of venous thromboembolism (VTE). Analysis of blood, to identify plasma proteins with potential utility for such tools, could enable an individualized approach to treatment ...

    • A single-cell type transcriptomics map of human tissues 

      Karlsson, Max; Cheng, Zhang; Mear, Lorén; Zhong, Wen; Digre, Andreas; Katona, Barbola; Sjöstedt, Evelina; Butler, Lynn; Odeberg, Jacob; Dusart, Philip James; Edfors, Fredrik; Oksvold, Per; von Feilitzen, Kalle; Zwahlen, Martin; Arif, Muhammad; Altay, Ozlem; Li, Xiangyu; Ozcan, Mehmet; Mardinoglu, Adil; Fagerberg, Linn; Mulder, Jan; Luo, Younglun; Ponten, Fredrik; Uhlén, Mathias; Lindskog, Cecilia (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-28)
      Advances in molecular profiling have opened up the possibility to map the expression of genes in cells, tissues, and organs in the human body. Here, we combined single-cell transcriptomics analysis with spatial antibodybased protein profiling to create a high-resolution single–cell type map of human tissues. An open access atlas has been launched to allow researchers to explore the expression of ...

    • Systematic development of sandwich immunoassays for the plasma secretome 

      Häussler, Ragna S.; Bendes, Annika; Iglesias, Maria Jesus; Sanchez-Rivera, Laura; Dodig‐Crnković, Tea; Byström, Sanna; Fredolini, Claudia; Birgersson, Elin; Dale, Matilda; Edfors, Fredrik; Fagerberg, Linn; Rockberg, Johan; Tegel, Hanna; Uhlén, Mathias; Qundos, Ulrika; Schwenk, Jochen M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-06)
      The plasma proteome offers a clinically useful window into human health. Recent advances from highly multiplexed assays now call for appropriate pipelines to validate individual candidates. Here, a workflow is developed to build dual binder sandwich immunoassays (SIA) and for proteins predicted to be secreted into plasma. Utilizing suspension bead arrays, ≈1800 unique antibody pairs are first screened ...